5/11/2025
Last update
5/11/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 20 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
L-Carnitine (Carnipure®)(from 1,493 mg L-Carnitine Tartrate)
1 g (1,000 mg)
**
Top Medical Research Studies
9
We investigated the effects of acetyl L-carnitine (ALC) on elderly patients experiencing chronic fatigue. In our study of 96 participants aged 70 and above, we found that ALC significantly reduced both physical and mental fatigue.
After treatment, improvements were noted in functional abilities and cognitive performance, with patients experiencing less muscle pain and fewer sleep disorders. Overall, our findings indicate that ALC can be an effective option for alleviating fatigue and enhancing quality of life in older individuals.
After treatment, improvements were noted in functional abilities and cognitive performance, with patients experiencing less muscle pain and fewer sleep disorders. Overall, our findings indicate that ALC can be an effective option for alleviating fatigue and enhancing quality of life in older individuals.
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7
We analyzed the clinical features of 82 patients with chronic fatigue syndrome (CFS) to explore potential treatment options like L-carnitine. Most patients exhibited common symptoms, including fatigue and memory issues, alongside psychological abnormalities. Notably, we found that L-carnitine levels were significantly lower among CFS patients compared to healthy controls.
After two weeks of supplementation, L-carnitine levels rose and symptoms showed improvement. While further research is necessary, these initial findings suggest that L-carnitine might play a positive role in managing CFS symptoms.
After two weeks of supplementation, L-carnitine levels rose and symptoms showed improvement. While further research is necessary, these initial findings suggest that L-carnitine might play a positive role in managing CFS symptoms.
Read More
9
We aimed to explore how L-carnitine supplementation affects individuals suffering from chronic fatigue syndrome (CFS) by analyzing their serotonin levels and fatigue symptoms. Our study focused on a group of 12 individuals with CFS and compared their serotonin and fatigue levels before and after 7 weeks of L-carnitine treatment.
Remarkably, we observed that after the supplementation, serotonin levels in those with CFS increased drastically—by eight times! Alongside this boost in serotonin, participants reported a significant two-fold reduction in fatigue symptoms, which was noteworthy given the persistent fatigue commonly experienced in CFS.
These findings also revealed a strong negative correlation between serotonin levels and fatigue, suggesting that higher serotonin is associated with lower fatigue levels. This paints a promising picture of L-carnitine as a potential treatment for managing fatigue in CFS, contributing to a better quality of life for those affected.
Remarkably, we observed that after the supplementation, serotonin levels in those with CFS increased drastically—by eight times! Alongside this boost in serotonin, participants reported a significant two-fold reduction in fatigue symptoms, which was noteworthy given the persistent fatigue commonly experienced in CFS.
These findings also revealed a strong negative correlation between serotonin levels and fatigue, suggesting that higher serotonin is associated with lower fatigue levels. This paints a promising picture of L-carnitine as a potential treatment for managing fatigue in CFS, contributing to a better quality of life for those affected.
Read More
Most Useful Reviews
9
Reduced exercise fatigue
21 people found this helpful
I'm impressed with the results! From the first dose, I noticed a difference. At over 55 years old, previous supplements caused heart palpitations. This product brought no discomfort to my heart, and after 45 minutes of cardio, my pulse didn't race, and I experienced no fatigue. The effect is astonishing, especially for evening workouts after a long day at work. The large tablets are easy to swallow with ample water. I believe the value for money is evident, and I will continue taking this product.
Read More
9
Enhanced mental clarity
13 people found this helpful
Undoubtedly, the quality is excellent! It enhances my clarity of mind and keeps me alert. The ingredients are top-notch, and there are no unpleasant tastes. I noticed increased endurance during both mental tasks and physical activities, and particularly no fatigue during my fitness classes! The tablet size is quite acceptable. The benefits are palpable; it’s difficult to describe how remarkable this product is. Many thanks to iHerb!
Read More
9
Excellent energy boost
6 people found this helpful
I highly recommend this product for those suffering from lethargy and constant fatigue. The quality and ingredients are outstanding, providing amazing energy, especially during gym sessions. It has significantly helped me, though the serving size is large. Overall, it's an excellent dietary supplement.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
- All Researches
9
We aimed to explore how L-carnitine supplementation affects individuals suffering from chronic fatigue syndrome (CFS) by analyzing their serotonin levels and fatigue symptoms. Our study focused on a group of 12 individuals with CFS and compared their serotonin and fatigue levels before and after 7 weeks of L-carnitine treatment.
Remarkably, we observed that after the supplementation, serotonin levels in those with CFS increased drastically—by eight times! Alongside this boost in serotonin, participants reported a significant two-fold reduction in fatigue symptoms, which was noteworthy given the persistent fatigue commonly experienced in CFS.
These findings also revealed a strong negative correlation between serotonin levels and fatigue, suggesting that higher serotonin is associated with lower fatigue levels. This paints a promising picture of L-carnitine as a potential treatment for managing fatigue in CFS, contributing to a better quality of life for those affected.
Remarkably, we observed that after the supplementation, serotonin levels in those with CFS increased drastically—by eight times! Alongside this boost in serotonin, participants reported a significant two-fold reduction in fatigue symptoms, which was noteworthy given the persistent fatigue commonly experienced in CFS.
These findings also revealed a strong negative correlation between serotonin levels and fatigue, suggesting that higher serotonin is associated with lower fatigue levels. This paints a promising picture of L-carnitine as a potential treatment for managing fatigue in CFS, contributing to a better quality of life for those affected.
Read More
9
We investigated the effects of acetyl L-carnitine (ALC) on elderly patients experiencing chronic fatigue. In our study of 96 participants aged 70 and above, we found that ALC significantly reduced both physical and mental fatigue.
After treatment, improvements were noted in functional abilities and cognitive performance, with patients experiencing less muscle pain and fewer sleep disorders. Overall, our findings indicate that ALC can be an effective option for alleviating fatigue and enhancing quality of life in older individuals.
After treatment, improvements were noted in functional abilities and cognitive performance, with patients experiencing less muscle pain and fewer sleep disorders. Overall, our findings indicate that ALC can be an effective option for alleviating fatigue and enhancing quality of life in older individuals.
Read More
8
ACCAR surpasses amantadine for fatigue
We explored the effectiveness of acetyl L-carnitine (ALCAR) in treating fatigue among patients with multiple sclerosis, comparing it to amantadine. In a robust randomized, double-blind, crossover trial involving 36 participants, ALCAR showed a significant improvement in fatigue levels on the Fatigue Severity Scale after three months compared to amantadine. However, when looking at secondary outcomes, like depression and social experiences, no significant differences were noted. Overall, ALCAR proved to be better tolerated and more effective for managing fatigue in this population.
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8
We evaluated how L-carnitine impacts fatigue in patients undergoing treatment for chronic hepatitis C. The study involved 50 patients split into two groups: one received just interferon-alpha, while the other received interferon alongside L-carnitine.
We discovered that those taking L-carnitine reported a significant reduction in fatigue levels, particularly noticed early on in treatment. By contrasting these observations, we suggested that L-carnitine may enhance energy levels, effectively helping alleviate treatment-induced fatigue in these patients.
We discovered that those taking L-carnitine reported a significant reduction in fatigue levels, particularly noticed early on in treatment. By contrasting these observations, we suggested that L-carnitine may enhance energy levels, effectively helping alleviate treatment-induced fatigue in these patients.
Read More
7
We set out to explore how l-carnitine, a common dietary supplement, affects individuals suffering from chronic fatigue syndrome (CFS). By conducting a systematic review of fourteen studies involving 809 participants, we aimed to gather reliable evidence about the effectiveness of l-carnitine in alleviating fatigue, one of the primary symptoms of this complex disorder.
Many patients turn to dietary supplements like l-carnitine to find relief from their fatigue and its accompanying symptoms. Our review found that while some studies reported a significant reduction in fatigue from interventions that included l-carnitine, we also noticed methodological challenges that limit these findings. Issues such as small sample sizes and missing data led to a high risk of bias, which makes it hard to draw clear conclusions about the supplement's effectiveness on its own.
Additionally, our review highlighted mixed results when it came to secondary outcomes, such as cognitive function and biomarkers of inflammation. Some participants did report adverse effects, like nausea and insomnia, which adds another layer of complexity in assessing the use of l-carnitine for CFS. Overall, while l-carnitine shows potential benefits for reducing fatigue, the limitations of the current studies make us cautious about confirming its isolated effectiveness.
Many patients turn to dietary supplements like l-carnitine to find relief from their fatigue and its accompanying symptoms. Our review found that while some studies reported a significant reduction in fatigue from interventions that included l-carnitine, we also noticed methodological challenges that limit these findings. Issues such as small sample sizes and missing data led to a high risk of bias, which makes it hard to draw clear conclusions about the supplement's effectiveness on its own.
Additionally, our review highlighted mixed results when it came to secondary outcomes, such as cognitive function and biomarkers of inflammation. Some participants did report adverse effects, like nausea and insomnia, which adds another layer of complexity in assessing the use of l-carnitine for CFS. Overall, while l-carnitine shows potential benefits for reducing fatigue, the limitations of the current studies make us cautious about confirming its isolated effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced exercise fatigue
21 people found this helpful
I'm impressed with the results! From the first dose, I noticed a difference. At over 55 years old, previous supplements caused heart palpitations. This product brought no discomfort to my heart, and after 45 minutes of cardio, my pulse didn't race, and I experienced no fatigue. The effect is astonishing, especially for evening workouts after a long day at work. The large tablets are easy to swallow with ample water. I believe the value for money is evident, and I will continue taking this product.
Read More
9
Enhanced mental clarity
13 people found this helpful
Undoubtedly, the quality is excellent! It enhances my clarity of mind and keeps me alert. The ingredients are top-notch, and there are no unpleasant tastes. I noticed increased endurance during both mental tasks and physical activities, and particularly no fatigue during my fitness classes! The tablet size is quite acceptable. The benefits are palpable; it’s difficult to describe how remarkable this product is. Many thanks to iHerb!
Read More
9
Excellent energy boost
6 people found this helpful
I highly recommend this product for those suffering from lethargy and constant fatigue. The quality and ingredients are outstanding, providing amazing energy, especially during gym sessions. It has significantly helped me, though the serving size is large. Overall, it's an excellent dietary supplement.
Read More
7.5
Relieves lethargy
4 people found this helpful
I recommend this product to anyone dealing with lethargy and constant fatigue. The quality and ingredients are excellent, providing remarkable energy, especially while I am at the gym. It has significantly helped me, though I find the serving size too large, but overall it's a fantastic supplement.
Read More
9
Increases stamina and strength
1 people found this helpful
I take this product pre-workout to enhance my stamina, strength, and energy. The results have been excellent, taking it 30 minutes before exercising. My training sessions fly by, and I experience immense strength without fatigue. It also aids in fat burning when combined with proper nutrition.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Dorczok MC, Mittmann G, Mossaheb N, Schrank B, Bartova L, et al. Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review. Nutrients. 2025;17. 10.3390/nu17030475
- Raij T, Raij K. Association between fatigue, peripheral serotonin, and L-carnitine in hypothyroidism and in chronic fatigue syndrome. Front Endocrinol (Lausanne). 2024;15:1358404. 10.3389/fendo.2024.1358404
- Leombruni P, Miniotti M, Colonna F, Sica C, Castelli L, et al. A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: preliminary data. Clin Exp Rheumatol. 2015;33:S82.
- Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46:181.
- Li YJ, Wang DX, Bai XL, Chen J, Liu ZD, et al. [Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases]. Zhonghua Yi Xue Za Zhi. 2005;85:701.
- Vermeulen RC, Scholte HR. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. 2004;66:276.
- Tomassini V, Pozzilli C, Onesti E, Pasqualetti P, Marinelli F, et al. Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. J Neurol Sci. 2004;218:103.
- Neri S, Pistone G, Saraceno B, Pennisi G, Luca S, et al. L-carnitine decreases severity and type of fatigue induced by interferon-alpha in the treatment of patients with hepatitis C. Neuropsychobiology. 2003;47:94.
